…progressively as kidney function declines and as albuminuria increases. When eGFR falls below approximately 60–75 mL/min/1.73 m², the probability of coronary…

…or III HFrEF, a previous heart failure hospitalisation, sinus rhythm and a heart rate above 70 beats/min. The reduction in the combined outcome of…

…times daily See note Do not use Do not use Nitrofurantoin: as a general rule the drug is contraindicated at an eGFR <45 mL/min…

…pathological Q waves. Pathological Q waves are ≥0,03 s and/or amplitude ≥25% of R wave amplitude in the same lead, in at least…

…risk of respiratory depression. Avoid the combination, or reduce both Red flags and pitfalls A respiratory rate < 8/min, or an increasing level of…

…m/s or a valve area < 1.0 cm² with a mean gradient ≥ 40 mmHg. Fluid responsiveness Static measures such as the CVP predict…

…35 mm. Q waves: pathological Q waves (≥ 0.03 s and/or an amplitude ≥ 25 % of the R wave amplitude in the same lead, in…

…signs of deep vein thrombosis 3 Pulmonary embolism is the most likely diagnosis 3 Heart rate 100/min 1.5 Immobilisation ≥ 3 days or surgery…

…or to confirm a creatinine based value The mean of creatinine and cystatin C The most reliable in routine clinical practice Cockcroft–Gault Still used…

…or nasal polyps (increased risk of hypersensitivity reactions, such as asthma attacks, angioedema, or urticaria with NSAIDs). Alcohol consumption may increase the risk of gastrointestinal…