17 träffar

DrugEndogenous purine nucleoside, AV-nodal blocking agent
Adenosine

…is slowed. The half-life of a few seconds means both the effect and side effects are over before one can regret it, but requires…

DrugHMG-CoA reductase inhibitor
Atorvastatin

…Krka HMG-CoA reductase inhibitor High-intensity statin with a long half-life, allowing it to be taken at any time of day unlike simvastatin…

DrugDihydropyridine calcium channel blocker, ultra-short-acting
Clevidipine

…acting dihydropyridine broken down by esterases in blood and tissue — the half-life is 5 minutes and the effect can be steered minute by minute…

DrugUltra-short-acting β₁-selective blocker
Esmolol

…short-acting β₁-selective blocker The beta-blocker to choose when reversibility matters. With a half-life of 9 minutes and the effect gone 20…

DrugRecombinant tissue plasminogen activator (rt-PA)
Alteplase

…mg — and confusing them is the most common serious error. The short half-life means the effect cannot be reversed once the dose is given.

DrugClass III antiarrhythmic
Amiodarone

…intravenous use with properties from classes I–IV. Extensive tissue distribution and a half-life measured in weeks — initiation and discontinuation have consequences for months.

DrugLong-acting dihydropyridine calcium channel blocker
Amlodipine

…hypertension and stable angina, and the easiest calcium channel blocker to use: once-daily dosing, a half-life of almost two days, and no dose…

DrugDirect factor Xa inhibitor
Apixaban

…dosing and no routine monitoring. Lower risk of intracranial haemorrhage than warfarin — but the short half-life means a missed dose has consequences within hours.

DrugHighly selective β₁-blocker
Bisoprolol

…effect relationship without the CYP2D6-dependent variability that makes metoprolol response unpredictable. The half-life of 10–12 hours is sufficient for once-daily dosing.

DrugBroad-spectrum tetracycline
Doxycycline

…and Borrelia. Near-complete oral absorption and a long half-life make once-daily dosing possible. It is the standard choice in pneumonia in penicillin…

DrugIndirect thrombin and factor Xa inhibitor via antithrombin
Heparin (unfractionated)

…and factor Xa inhibitor via antithrombin The anticoagulant to choose when the ability to reverse rapidly matters: the half-life is one to two hours…

DrugNon-selective COX inhibitor, propionic acid derivative
Ibuprofen

…line NSAID in Sweden and the one with the least cardiovascular risk at a low dose. A short half-life of around 2 hours means…

DrugRapid-acting insulin analogue
Insulin aspart

…20 minutes and a duration of 3–5 hours; intravenously the half-life is a few minutes, which makes the infusion fully controllable but also…

DrugNMDA-receptor antagonist, dissociative anaesthetic
Ketamine

…septic, or otherwise preload-dependent patient, and the bronchodilation makes it valuable in life-threatening asthma. Respiratory drive and laryngeal reflexes are largely preserved, which…

DrugLong-acting benzodiazepine with active metabolite
Diazepam

…compound has a half-life of one to two days and the active metabolite desmethyldiazepam up to four, so the concentration continues to rise for…

DrugAngiotensin II-receptorblockerare (ARB)
🇸🇪 Losartan

…och är den enda ARB som sänker urat i stället för att höja det. Vid hypertoni med vänsterkammarhypertrofi finns dessutom LIFE-studiens dokumentation på strokeprevention.

DrugElectrolyte concentrate for potassium replacement
Potassium chloride

…up to 20 mmol per hour, and at most 40 mmol per hour in life-threatening hypokalaemia under continuous ECG monitoring. Hypokalaemia that refuses to…