17 träffar

DrugEndogenous purine nucleoside, AV-nodal blocking agent
Adenosine

…flutter and atrial tachycardia are unmasked when the ventricular response is slowed. The half-life of a few seconds means both the effect and side…

DrugHMG-CoA reductase inhibitor
Atorvastatin

Lipitor Atorvastatin Krka HMG-CoA reductase inhibitor High-intensity statin with a long half-life, allowing it to be taken at any time of day…

DrugDihydropyridine calcium channel blocker, ultra-short-acting
Clevidipine

…acting dihydropyridine broken down by esterases in blood and tissue — the half-life is 5 minutes and the effect can be steered minute by minute…

DrugUltra-short-acting β₁-selective blocker
Esmolol

…choose when reversibility matters. With a half-life of 9 minutes and the effect gone 20–30 minutes after the infusion ends, it is useful…

DrugRecombinant tissue plasminogen activator (rt-PA)
Alteplase

…pulmonary embolism and myocardial infarction use a fixed 100 mg — and confusing them is the most common serious error. The short half-life means the…

DrugClass III antiarrhythmic
Amiodarone

…for oral and intravenous use with properties from classes I–IV. Extensive tissue distribution and a half-life measured in weeks — initiation and discontinuation have…

DrugLong-acting dihydropyridine calcium channel blocker
Amlodipine

…for hypertension and stable angina, and the easiest calcium channel blocker to use: once-daily dosing, a half-life of almost two days, and no…

DrugDirect factor Xa inhibitor
Apixaban

…Xa inhibitor with fixed dosing and no routine monitoring. Lower risk of intracranial haemorrhage than warfarin — but the short half-life means a missed dose…

DrugHighly selective β₁-blocker
Bisoprolol

…between liver and kidney, giving a predictable dose–effect relationship without the CYP2D6-dependent variability that makes metoprolol response unpredictable. The half-life of 10…

DrugBroad-spectrum tetracycline
Doxycycline

…oral absorption and a long half-life make once-daily dosing possible. It is the standard choice in pneumonia in penicillin-allergic patients and in…

DrugIndirect thrombin and factor Xa inhibitor via antithrombin
Heparin (unfractionated)

…rapidly matters: the half-life is one to two hours, the effect can be measured in real time with APTT, and it can be neutralised…

DrugNon-selective COX inhibitor, propionic acid derivative
Ibuprofen

…and the one with the least cardiovascular risk at a low dose. A short half-life of around 2 hours means the effect arrives and…

DrugRapid-acting insulin analogue
Insulin aspart

…ketoacidosis and hyperosmolar hyperglycaemic state. Subcutaneously it has an onset within 10–20 minutes and a duration of 3–5 hours; intravenously the half-life…

DrugNMDA-receptor antagonist, dissociative anaesthetic
Ketamine

…otherwise preload-dependent patient, and the bronchodilation makes it valuable in life-threatening asthma. Respiratory drive and laryngeal reflexes are largely preserved, which is an…

DrugLong-acting benzodiazepine with active metabolite
Diazepam

…it is something entirely different: the parent compound has a half-life of one to two days and the active metabolite desmethyldiazepam up to four…

DrugAngiotensin II-receptorblockerare (ARB)
🇸🇪 Losartan

…och är den enda ARB som sänker urat i stället för att höja det. Vid hypertoni med vänsterkammarhypertrofi finns dessutom LIFE-studiens dokumentation på strokeprevention.

DrugElectrolyte concentrate for potassium replacement
Potassium chloride

…10 mmol per hour, in a central vein up to 20 mmol per hour, and at most 40 mmol per hour in life-threatening hypokalaemia…