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Diuretic Strategy and Decongestion in Heart Failure

…of extracellular volume expansion include elevated cardiac filling pressures, pulmonary congestion, systemic venous hypertension, and peripheral interstitial edema. These abnormalities produce breathlessness, orthopnea, weight gain…

ST-Elevation Myocardial Infarction: Diagnosis and Electrocardiographic Criteria

…thrombotic debris may worsen the obstruction. Furthermore, cardiomyocyte swelling, interstitial edema, and tissue inflammation promote extravascular compression, exacerbating myocardial injury. Clinical Presentation and Symptoms In…

ST-Segment Elevation Myocardial Infarction: Diagnosis and ECG Criteria

…environmental factors and genetic background. Thrombotic susceptibility is likewise affected by inflammation and other systemic influences. The severity of myocardial injury is determined not only…

Anticoagulation Strategies in Atrial Fibrillation

…hypertension, heart failure, and the arrhythmia itself. This remodeling manifests as interstitial fibrosis, atrial dilation, and endocardial denudation, which collectively promote local inflammation and create…

Non-ST Elevation Acute Myocardial Infarction (NSTEMI) and Unstable Angina

…fibrous cap measuring less than 65 micrometers in thickness. Macrophage derived matrix metalloproteinases (MMPs) degrade the interstitial collagen of the cap, leading to structural failure…

Hypoglycaemia: quick reference for emergency management

…alcohol, a missed meal, physical activity and any other precipitating factor. Thresholds The thresholds below are used above all in diabetes. The severity of the…

ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock

…Other causes include acute mechanical complications—particularly ventricular septal defect (VSD) and papillary muscle rupture with acute severe mitral regurgitation—predominant right ventricular (RV) infarction…

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…other cytokines. Within the intima, SMCs undergo a phenotypic switch from a contractile to a synthetic state, producing abundant extracellular matrix (ECM) components, primarily interstitial…

Contrast-Associated Acute Kidney Injury: Risk Assessment and Prevention

…cardiac dysfunction, haemodynamic instability, anaemia and other nephrotoxic exposures may contribute to tubular injury, making attribution to contrast alone difficult. In patients with normal renal…

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