…and Pathophysiological Basis High sensitivity cardiac troponin (hs cTn) assays detect circulating troponin released from injured cardiomyocytes at substantially lower concentrations than earlier generation assays…

…for myocardial injury. Interpretation of troponin T is more complex because injured skeletal muscle may express proteins detected by some troponin T assays. Troponin can…

…accompanied by compensatory hyperinsulinaemia and, with progression, hyperglycaemia and pancreatic β cell dysfunction. These abnormalities initiate self perpetuating metabolic and inflammatory pathways that injure the…