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Cardiovascular Risk in Inflammatory and Autoimmune Disease

Cardiology Clinical medicine Definition and scope Inflammatory and autoimmune diseases are immune mediated inflammatory diseases (IMIDs) that include rheumatoid arthritis (RA), psoriatic arthritis, spondyloarthropathies, systemic…

Colchicine and Anti-inflammatory Therapy in Coronary Disease

…innate immune pathways, cytokine signalling and recruitment of inflammatory cells to vascular lesions. The interleukin 1β pathway, with downstream effects involving interleukin 6 and…

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…severity of baseline stenosis does not reliably predict the site of future STEMI; rather, it is the biological composition and inflammatory activity of the plaque…

Post-Infarction Pericarditis and Dressler Syndrome

…weeks, improvement with anti inflammatory treatment, and the tendency to recur all support an immunopathological mechanism. The precise cause, however, is not fully established. At…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…intima, differentiate into macrophages and participate in a sustained inflammatory response. Lipid accumulation, oxidative stress and immune activation progressively alter the local vascular environment. The…

Introduction to Coronary Artery Disease (Ischemic Heart Disease)

…is a chronic inflammatory disease of the arteries. It has become increasingly clear in the past few decades that atherosclerosis is not caused by the…

Isoprenaline and Dopamine Infusions for Bradycardia

…His Purkinje system. The underlying pathophysiology varies widely and may involve intrinsic cardiac disease, extrinsic systemic conditions, or pharmacologic effects. Inflammatory heart disease, caused by…

Preeclampsia and Hypertensive Pregnancy Disorders as Future Cardiovascular Risk

…uteroplacental ischaemia, an exaggerated maternal inflammatory response, and disturbed angiogenic signalling. A central biochemical feature is an imbalance between antiangiogenic and angiogenic factors. Placental production…

ApoB and Non-HDL Cholesterol in Cardiovascular Risk Assessment

…an incomplete representation of atherogenic burden. Clinical Presentation and Symptoms ApoB elevation and increased non HDL C are laboratory abnormalities and do not produce specific

Cardiac arrest in hyperthermia and malignant hyperthermia

…can induce an inflammatory state similar to the Systemic Inflammatory Response Syndrome (SIRS). Body temperatures surpassing 40°C (104°F) are potentially hazardous and may precipitate cardiac…

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