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Refractory Angina: Options When Standard Therapy Fails

…CAD. The pathophysiology of refractory angina is heterogeneous. In obstructive CAD, symptoms may result from extensive or diffuse epicardial disease, chronic total occlusion, incomplete revascularization…

Myocardial Infarction with Non-Obstructive Coronary Arteries: Causes, Work-up and Management

…despite the absence of an angiographically obstructive lesion Coronary embolism or thrombus Epicardial coronary vasospasm Coronary microvascular dysfunction Spontaneous coronary artery dissection (SCAD) Standard angiography…

In-Stent Restenosis: Mechanisms and Treatment

…collapse Residual edge dissection Incomplete lesion preparation Persistent stenosis within the treated segment Mechanical factors are particularly important because correction of the underlying problem is…

Stent Thrombosis: Timing, Causes, Diagnosis, and Prevention

…aspirin or clopidogrel Anatomic Long lesions, small vessels, multivessel disease, bifurcation lesions, treatment of acute myocardial infarction Procedural and mechanical Stent underexpansion, incomplete wall apposition…

Complete Versus Culprit-Only Revascularization in Acute Coronary Syndrome

…total occlusion is an important predictor of incomplete anatomical revascularization with PCI. PCI of chronic total occlusion lesions may improve angina and quality of life…

Vasospastic (Prinzmetal) Angina: Provocation Testing and Treatment

…with intermediate lesions that do not produce physiologically significant flow limitation. The mechanisms are incompletely defined. Proposed contributors include hypercontractility or hypersensitivity of coronary vascular…

Opioids in acute pain: quick reference for dosing and conversion

…approximate. When switching between opioids, cross tolerance is incomplete: reduce the calculated equianalgesic dose by 25–50 per cent and titrate. At a high dose…

Quiz: ECG in athletes

…to ECG interpretation 1. Which of the following ECG findings is typically considered a normal variant in asymptomatic athletes with no significant family history? A:…

Pericardial Effusion & Cardiac tamponade

…cysts and tumors of the pericardium, as well as congenital malformations leading to an incomplete or absent pericardium. In case of suspicion of pericardial disease…

Opioid therapy in severe pain

…is given. The serious incidents almost always arise when the principle of titration is abandoned — when a fixed dose is given without assessment, when a…

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