…often occurring before age 30. Clinical presentation and symptoms Heterozygous familial hypercholesterolaemia Many individuals with HeFH are asymptomatic until ASCVD develops. The clinical phenotype is…

…Individuals with familial hypercholesterolemia may have either one defect gene copy (heterozygous FH) or two defect gene copies (homozygous FH). Heterozygous FH results in high…

…when additional LDL C reduction is required, including in patients with atherosclerotic cardiovascular disease (ASCVD) or heterozygous familial hypercholesterolaemia. The broader therapeutic principle is that…

Cardiology Genetic and miscellaneous conditions Definition and scope Familial and genetic screening in cardiovascular medicine is the systematic assessment of relatives and other individuals who…