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Heart Failure With Mildly Reduced Ejection Fraction

…or hepatic disease may produce a similar symptom complex; in the absence of cardiac dysfunction, these conditions do not fulfil the definition of heart failure…

Poisoning: quick reference for antidotes and initial management

…a threatened airway, a marked risk of aspiration, or failure that is not rapidly reversed by an antidote B Respiratory rate, saturation, chest movement and…

Warfarin therapy

…1 and 2 in patients over 75, with a weight below 60 kg, heart failure, hepatic impairment, malnutrition, concurrent amiodarone or known slow CYP2C9 metabolism…

Renal parameters

…amputees, patients with hepatic cirrhosis — creatinine based eGFR substantially overestimates renal function. Staging of chronic kidney disease Stage eGFR Description : : : G1 ≥ 90 Normal or high…

Alcohol and Cardiovascular Disease

…adverse effects on stroke, heart failure, cardiovascular mortality and atrial fibrillation. Consequently, alcohol should not be initiated as a cardiovascular preventive strategy. A drink equivalent…

Metabolic Syndrome: Definition and Clinical Significance

…coexistence of defined clinical and laboratory components; the diagnostic criteria themselves are not reproduced in the available source material. Waist circumference is particularly important because…

Ezetimibe: Place in Therapy and Expected LDL-C Reduction

…of cholesterol delivered to the liver. The resulting hepatic response includes increased expression of low density lipoprotein receptors (LDLRs), which enhances removal of circulating LDL…

Stroke Prevention in Atrial Fibrillation: Choosing Anticoagulation

…pattern does not determine the anticoagulation indication. Previous stroke or TIA. The presence of mitral stenosis, a mechanical heart valve or hypertrophic cardiomyopathy. Heart failure…

Sepsis and septic shock: quick reference for the first hour

…The patient need not have fever, leucocytosis or a positive culture. Older people, the immunosuppressed and patients with renal or hepatic failure can have subtle…

Ivabradine: Indications, Dosing and Heart-Rate Targets

…is required in severe hepatic or renal impairment, and clinically relevant interactions occur with CYP3A4 inhibitors and inducers. Clinical indications Heart failure with reduced ejection…

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