17 träffar

DrugHMG-CoA reductase inhibitor
Atorvastatin

Lipitor Atorvastatin Krka HMG-CoA reductase inhibitor High-intensity statin with a long half-life, allowing it to be taken at any time of day…

DrugClass III antiarrhythmic
Amiodarone

…intravenous use with properties from classes I–IV. Extensive tissue distribution and a half-life measured in weeks — initiation and discontinuation have consequences for months.

DrugDihydropyridine calcium channel blocker, ultra-short-acting
Clevidipine

…acting dihydropyridine broken down by esterases in blood and tissue — the half-life is 5 minutes and the effect can be steered minute by minute…

DrugUltra-short-acting β₁-selective blocker
Esmolol

…choose when reversibility matters. With a half-life of 9 minutes and the effect gone 20–30 minutes after the infusion ends, it is useful…

DrugNon-selective α-adrenergic blocker
Phentolamine

Regitin Rogitine OraVerse Non-selective α-adrenergic blocker Non-selective alpha-blocker with onset within minutes and duration under half an hour. A niche drug…

DrugEndogenous purine nucleoside, AV-nodal blocking agent
Adenosine

…is slowed. The half-life of a few seconds means both the effect and side effects are over before one can regret it, but requires…

DrugRecombinant tissue plasminogen activator (rt-PA)
Alteplase

…mg — and confusing them is the most common serious error. The short half-life means the effect cannot be reversed once the dose is given.

DrugLong-acting dihydropyridine calcium channel blocker
Amlodipine

…and the easiest calcium channel blocker to use: once-daily dosing, a half-life of almost two days, and no dose adjustment in renal impairment…

DrugDirect factor Xa inhibitor
Apixaban

…dosing and no routine monitoring. Lower risk of intracranial haemorrhage than warfarin — but the short half-life means a missed dose has consequences within hours.

DrugHighly selective β₁-blocker
Bisoprolol

…effect relationship without the CYP2D6-dependent variability that makes metoprolol response unpredictable. The half-life of 10–12 hours is sufficient for once-daily dosing.

DrugLong-acting benzodiazepine with active metabolite
Diazepam

…standing treatment it is something entirely different: the parent compound has a half-life of one to two days and the active metabolite desmethyldiazepam up…

DrugBroad-spectrum tetracycline
Doxycycline

…and Borrelia. Near-complete oral absorption and a long half-life make once-daily dosing possible. It is the standard choice in pneumonia in penicillin…

DrugIndirect thrombin and factor Xa inhibitor via antithrombin
Heparin (unfractionated)

…and factor Xa inhibitor via antithrombin The anticoagulant to choose when the ability to reverse rapidly matters: the half-life is one to two hours…

DrugNon-selective COX inhibitor, propionic acid derivative
Ibuprofen

…cardiovascular risk at a low dose. A short half-life of around 2 hours means the effect arrives and resolves quickly, which is an advantage:…

DrugRapid-acting insulin analogue
Insulin aspart

…20 minutes and a duration of 3–5 hours; intravenously the half-life is a few minutes, which makes the infusion fully controllable but also…

DrugSelektiv serotoninåterupptagshämmare (SSRI)
🇸🇪 Sertraline

…i normaldos och säkerhetsdata efter hjärtinfarkt. Vid ångesttillstånd är den avgörande detaljen inte måldosen utan starten: halv dos första veckan, annars driver den initiala oroförstärkningen…

DrugCalcium salt for intravenous membrane stabilisation and calcium supplementation
Calcium gluconate

…dialysis must be started in parallel, otherwise the arrhythmia risk returns when the calcium effect wanes after half an hour. Calcium gluconate contains approximately one…