…whereas heterozygous carriers of an X linked condition may develop a phenotype later and require delayed or individualized assessment. Disease specific genetic architecture HCM is…

…management because LDL and other apolipoprotein B containing lipoproteins play a causal role in atherosclerotic cardiovascular disease (ASCVD). This causal relationship is supported by genetic…

…as the procedure carries both benefits (life saving therapy) and risks (e.g., device related complications). Monitoring disease progression By periodically recalculating the SCD risk…

… enhancement of a prothrombotic state. Its atherogenic and inflammatory effects may be mediated partly by oxidized phospholipids carried on the particle. Genetic and Mendelian randomization…

…sporadic, age related disease characterized by a normal TTR genetic sequence [9, 19]. It is currently considered the most frequent form of CA worldwide [15]…

…the same broad category as a patient with coronary artery disease when clinically appropriate. Other coronary anomalies Anomalous coronary origin and course can impair coronary…

…The magnitude of untreated LDL C elevation. The presence and age of onset of premature CAD or other vascular disease. A history of myocardial infarction…

ECG Genetic and miscellaneous conditions J wave syndromes: early repolarization pattern, Brugada syndrome, hypercalcemia and hypothermia The J wave – also referred to as Osborn's…

…cardiac tamponade. The classical signs of cardiac tamponade are hypotension, muffled heart sounds and jugular venous distention. Other frequent symptoms are pulsus paradoxus, pericardial friction…

…refers to inflammation of the myocardial (muscle) tissue. However, it is often difficult to differentiate pericarditis and myocarditis, and they tend to accompany each other…