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Acute vertigo: quick reference for HINTS and differential diagnosis

…present, neurological examination, gait and truncal stability Acute balance syndrome Acute persistent unsteadiness or ataxia without clear spontaneous nystagmus Cerebellar or brainstem infarction, intoxication, Wernicke…

Hyponatraemia: quick reference for work-up and correction

…4. Where possible, take the plasma osmolality, urine osmolality and urine sodium before treatment. 5. With severe symptoms: give hypertonic saline immediately. Do not wait…

Peripheral Artery Disease: Diagnosis, Ankle–Brachial Index and Risk Management

…walking or a slow gait without describing classic claudication. In older adults, approximately 40% are asymptomatic, 50% report atypical leg symptoms and fewer than 10…

🟠 1-2-3-LQTS Risk Calculator

…LQT1) and KCNH2 (LQT2), and gain of function mutations in SCN5A (LQT3). These genetic anomalies disrupt the cardiac ion channels, leading to delayed repolarization and…

🟠 1-2-3-LQTS Risk Calculator

…LQT1) and KCNH2 (LQT2), and gain of function mutations in SCN5A (LQT3). These genetic anomalies disrupt the cardiac ion channels, leading to delayed repolarization and…

Diuretic Strategy and Decongestion in Heart Failure

…gain, peripheral edema, early satiety, abdominal distension and, in some patients, bendopnea. Congestion may also aggravate functional mitral regurgitation, ventricular dilatation, myocardial wall stress and…

Familial Hypercholesterolaemia: Diagnosis, Cascade Screening and Treatment

…binding to the LDL receptor. Gain of function variants in PCSK9, which reduce recycling and surface availability of hepatic LDL receptors. Rare biallelic variants in…

PCSK9 Inhibitors: Indications, Efficacy and Access

…the rationale for therapeutic inhibition. Gain of function PCSK9 mutations are associated with familial hypercholesterolaemia (FH) and premature coronary heart disease, whereas loss of function…

Assessment of diastolic function by echocardiography

…Gain and filter should be minimized in order to obtain optimal images. The pulsed Doppler beam can be positioned using color Doppler (to visualize the…

Optimization of the ultrasound image

…gain applied to incoming sound waves. This is done using gain control or time gain compensation (TGC) . Figure 1. TGC (time gain compensation) and gain…

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