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Bempedoic Acid: Evidence and Clinical Use

…is a prodrug activated predominantly in the liver by very long chain acyl CoA synthetase 1. This activating enzyme is not expressed in skeletal muscle…

Dietary Patterns and Cardiovascular Outcomes

…cumulative influence of multiple modest dietary changes. Mediterranean type diets provide polyphenols from extra virgin olive oil, fruits, vegetables, nuts and legumes; unsaturated fatty acids…

Hypertriglyceridaemia: Management and Cardiovascular Risk

…suppression is maintained. A change in antiretroviral therapy is not recommended in individuals with previous virological failure if it risks loss of suppression. Clinical presentation…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…vasoconstriction, adhesion of circulating cells, inflammatory cell entry into the intima, and thrombus formation. Atherosclerosis is therefore not simply a disorder of lipid storage. Its…

Metabolic Syndrome: Definition and Clinical Significance

…fatty liver disease is also independently related to cardiovascular disease, particularly coronary artery disease. Hyperuricaemia and Endothelial Dysfunction Insulin resistance impairs renal tubular handling of…

Coronary Artery Calcium Scoring: Prognostic Use in Practice

…fatty liver disease. Interpretation of the Agatston Score The score should be interpreted both by its absolute value and in relation to age and sex…

Incretins in Cardiometabolic Medicine: Leveraging GLP-1, GIP, and Glucagon Receptor Agonism for Cardiovascular Risk Reduction

…location of excess adiposity. 2 Clinical guidelines now emphasize that a BMI within the conventional "normal" range (up to 25 kg/m²) does not necessarily…

Intravascular Imaging: IVUS and OCT for PCI Optimisation

…mm, and may not show the EEM through substantial plaque or calcium. Blood clearance is required because blood causes strong backscatter of the light signal…

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…into characteristic foam cells. The accumulation of these foam cells forms the earliest macroscopically visible lesion of atherosclerosis: the fatty streak [5] . Ruptured atherosclerotic lesion…

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