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Cardiovascular Prevention in the Very Elderly

…pressures. Excessive reduction in diastolic blood pressure may compromise coronary perfusion, particularly in patients with coronary disease. Excessive systolic reduction may be associated with falls…

Risk Factor Modification: The Evidence Base for Primary Prevention

…is therefore directed at identifying individuals at increased risk and reducing exposure to established, modifiable determinants of cardiovascular disease. The principal targets include blood pressure…

LDL Cholesterol Targets Across Cardiovascular Risk Categories

…LDL C reduction. Thus, even a modest absolute reduction may be clinically important in individuals at high or very high risk. Prolonged exposure to lower…

Alcohol withdrawal and delirium tremens: quick reference

…abrupt reduction or cessation of prolonged and heavy alcohol intake. The condition can develop despite a measurable or high blood alcohol concentration, particularly in patients…

Arterial Hypertension: Definition, Diagnosis and Out-of-Office Measurement

…a risk based approach because cardiovascular benefit from blood pressure reduction may also occur in selected people whose pressure is elevated but below the conventional…

Vulnerable Plaque and Mechanisms of Acute Coronary Occlusion

…and infarction Definition and conceptual framework Acute coronary occlusion is the abrupt or progressive reduction of coronary blood flow sufficient to produce myocardial ischaemia and…

Anticoagulants: quick reference for dosing, renal adjustment and reversal

…reduction as in the table above for rivaroxaban and edoxaban. Check every 6 months 15 30 Dabigatran contraindicated. The other DOACs are possible according to…

Statin Intolerance and Statin-Associated Muscle Symptoms

…the rate limiting enzyme in cholesterol synthesis. Reduced hepatic cholesterol production increases hepatic LDL receptor expression, thereby enhancing removal of LDL particles from the circulation…

Smoking Cessation: Pharmacotherapy and Cardiovascular Benefit

…The principal benefits relevant to clinical cardiology include: Clinical setting or outcome Reported benefit of cessation Cardiovascular disease overall Substantial reduction in cardiovascular events and…

Alcohol and Cardiovascular Disease

…Acute ethanol exposure has a negative inotropic effect and promotes peripheral vasodilation through reduced systemic vascular resistance. The resulting mild reduction in blood pressure is…

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