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Obesity and Cardiovascular Disease: Assessment and Treatment

…disease characterized by excessive accumulation of adipose tissue. It is an important cause of cardiovascular disease (CVD), cardiovascular risk factor clustering, disability and premature mortality…

Diuretic Strategy and Decongestion in Heart Failure

…the intravascular and extravascular compartments. Heart failure is defined physiologically by the inability of the heart to provide blood flow appropriate to tissue requirements unless…

Sotalol: Initiation, QT Monitoring and Renal Dosing

…QT interval and the PR interval, while leaving the QRS duration largely unchanged. Continuous ECG monitoring is mandated during hospital initiation to detect excessive QT…

Drug-Eluting Coronary Stents: Evolution, Evidence and Stent Choice

…occurred in 10–15% during the first year. The dominant mechanism was excessive intimal hyperplasia within the stent. Restenosis was more likely with: Small reference…

Hypertriglyceridaemia: Management and Cardiovascular Risk

…disease Excessive alcohol consumption Diets high in carbohydrate or fat Glucocorticoids Beta blockers Oestrogen therapy Some antiretroviral therapies Post transplant medications, including corticosteroids, cyclosporine and…

Diabetic ketoacidosis and hyperosmolar hyperglycaemic state: quick reference

…2024, the diagnosis of DKA requires three components: diabetes or hyperglycaemia, ketosis and metabolic acidosis. A very high glucose value is no longer required [1]…

De-escalation and Shortened Dual Antiplatelet Therapy in Patients at High Bleeding Risk

…contraindication, an indication for oral anticoagulation, or an excessive risk of bleeding. The duration and intensity may be modified according to: bleeding risk; ischemic risk…

Unstable Angina: Definition and Contemporary Management

…Reduced exercise tolerance. Excessive fatigue. These non chest pain manifestations are reported more frequently in females, older adults and people with diabetes. Ischaemic heart disease…

Atrial Fibrillation in the Critically Ill Patient

…further assessment. Clinical presentation and symptoms The clinical presentation is heterogeneous. AF may be well tolerated, particularly when the ventricular response is not excessive, or…

ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock

…impaired tissue perfusion can extend injury beyond the initial ischemic zone and contributes to ventricular failure. Mechanisms of Shock The central consequence of extensive infarction…

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