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Stroke Prevention in Atrial Fibrillation: Choosing Anticoagulation

…clinical patterns of AF—paroxysmal, persistent, long standing persistent and permanent—and is not determined solely by the apparent frequency or duration of documented episodes…

Microvascular Angina and INOCA: Diagnosis with CFR and IMR

…symptoms such as dyspnoea and fatigue, as well as a greater prevalence of MVA. Symptoms may be persistent or episodic and may not follow a…

Acute vertigo: quick reference for HINTS and differential diagnosis

…Wernicke's encephalopathy, other central disease Neurological examination, gait and truncal stability, often MRI Episodic triggered vestibular syndrome Brief attacks, usually lasting seconds, reproducibly triggered…

Coronary Anatomy and Segmental Classification for the Clinician

…Angiography also provides limited information about plaque composition, vulnerability and the risk of future plaque rupture. Anatomical severity versus functional significance The physiological effect of…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…calcification and remodelling; episodic plaque disruption followed by thrombosis. Atherosclerotic disease usually evolves over decades. Intimal thickening may be present during the second and third…

Vasovagal Syncope: Diagnosis, Tilt Testing and Treatment

…autonomic dysregulation within a structurally normal heart. During an episode, decreased cardiac output and a potential paradoxical vasodilation with hypotension occur, often accompanied by bradycardia…

Acquired QT Prolongation and Drug-Induced Arrhythmia

…early afterdepolarisations (EADs) that generate premature ventricular contractions (PVCs) and increases transmural dispersion of repolarisation, thereby facilitating reentry. Episodes of TdP are frequently pause dependent…

Alcohol withdrawal and delirium tremens: quick reference

…hypoactivity, hallucinations and marked autonomic hyperactivity Up to 5 to 7 days, sometimes longer Persisting withdrawal, particularly after previous severe episodes, with concurrent physical illness…

Ischemic Cardiomyopathy: Myocardial Viability Assessment and Revascularization

…repeated ischemic episodes or chronic reductions in perfusion. The amount and distribution of both viable and nonviable myocardium, together with coronary anatomy and the feasibility…

Unstable Angina: Definition and Contemporary Management

…infarction (AMI), in which myocardial ischaemia is accompanied by cardiomyocyte necrosis and cardiac troponin release meeting the criteria of the universal definition of MI. Clinically…

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