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Vulnerable Plaque and Mechanisms of Acute Coronary Occlusion

…between myocardial oxygen supply and demand. In many cases, the initiating process is plaque disruption with thrombosis; other cases result from spasm, microvascular dysfunction, embolism…

Indications and contraindications for myocardial perfusion imaging

…failure Acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis Acute myocarditis or pericarditis Acute aortic dissection Physical disability that precludes safe and adequate testing…

Peripheral Artery Disease: Diagnosis, Ankle–Brachial Index and Risk Management

…Other mechanisms include thrombosis, embolism, vasculitis, fibromuscular dysplasia, arterial entrapment, cystic adventitial disease and trauma. Atherosclerotic PAD is a manifestation of systemic arterial disease rather…

Type 2 Myocardial Infarction: Mechanisms and Management

…smooth muscle cell dysfunction, and dysregulation of sympathetic innervation), coronary embolism, and spontaneous coronary artery dissection with or without intramural haematoma. Spontaneous coronary artery dissection…

Myocardial Infarction with Non-Obstructive Coronary Arteries: Causes, Work-up and Management

…include: Plaque rupture or plaque erosion with thrombosis, despite the absence of an angiographically obstructive lesion Coronary embolism or thrombus Epicardial coronary vasospasm Coronary microvascular…

ST-Segment Elevation Myocardial Infarction: Diagnosis and ECG Criteria

…plaque morphology and location, comorbidities, environmental factors and genetic background. Thrombotic susceptibility is likewise affected by inflammation and other systemic influences. The severity of myocardial…

Anticoagulants: quick reference for dosing, renal adjustment and reversal

…the bleeding risk of the procedure and by renal function. In markedly reduced renal function (dabigatran at eGFR <30 mL/min, the other DOACs at…

Indications, Contraindications, and Preparations for Exercise Stress Testing

…defibrillators and other emergency instruments. Personnel conducting the test must be formally trained to assess cardiovascular response, symptoms, and ECG changes. Although the risk of…

The Fourth Universal Definition of Myocardial Infarction: Types 1–5

…disruption of an atherosclerotic plaque through rupture or erosion. The relative contributions of plaque disease and thrombus vary considerably. Thrombotic material may embolize distally and…

Stent Thrombosis: Timing, Causes, Diagnosis, and Prevention

…of the stent, stent diameter less than 3 mm, long stent length Large thrombotic burdens increase procedural risk because thrombus can fragment, embolize to other…

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