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Metabolic Syndrome: Definition and Clinical Significance

…asymmetric dimethylarginine, homocysteine, white blood cell count, proinflammatory cytokines and C reactive protein. Increased urinary albumin/creatinine ratio reflects altered endothelial and renal pathophysiology in…

Secondary Hypertension: When and How to Investigate

…establish: Whether hypertension is genuinely present Factors that may be contributing to elevated blood pressure Other cardiovascular risk factors and relevant comorbidities Evidence of hypertension…

Arterial Hypertension: Definition, Diagnosis and Out-of-Office Measurement

Cardiology Definition and pathophysiology Blood pressure is a continuous cardiovascular exposure rather than a binary distinction between normotension and hypertension. Its long term relationship with…

Resistant Hypertension: Evaluation and Treatment

…In clinical practice, the condition is identified primarily through persistently elevated blood pressure despite multidrug treatment rather than through specific symptoms. The clinical importance lies…

Blood Pressure Targets in Older and Frail Adults

Cardiology Clinical medicine Definition and Clinical Context Blood pressure management in older adults must account for chronological age, biological age, frailty, multimorbidity, cognitive status, functional…

Heart Failure With Preserved Ejection Fraction: Diagnosis and Treatment

…been described in HFpEF, while nitrosative stress and abnormalities of cellular and molecular myocardial function may further impair contraction and relaxation. Structural and vascular consequences…

Hypertension: Initial Combination Therapy and Drug Selection

…clinician inertia and contributes to inadequate long term control. The treatment objective is individualized blood pressure reduction sufficient to reduce cardiovascular risk while preserving tolerability…

🟠 Mean arterial pressure (MAP) calculator

…and vascular resistance. Advantages of measuring MAP over systolic blood pressure While systolic blood pressure (SBP) indicates the maximum pressure during heart contraction, it does…

Microvascular Angina and INOCA: Diagnosis with CFR and IMR

…diabetes, and elevated NT proBNP are more frequent in this pattern. Endothelial dysfunction may contribute to both microvascular and epicardial vasomotor disorders. Endothelial activation can…

Right Ventricular Infarction: Recognition and Haemodynamic Management

…common in patients with inferoposterior left ventricular infarction, while infarction confined predominantly to the right ventricle is rare. The clinical spectrum extends from limited right…

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