…include depletion of glycogen, relaxation of myofibrils, and disruption of the sarcolemma. These changes may appear within 10–15 minutes of ischaemia. Mitochondrial abnormalities can…

…By definition, acute atherothrombotic plaque disruption is not a feature of Type 2 MI. The pathophysiology of Type 2 MI is fundamentally distinct from that…

…severe, myocardial necrosis. It most commonly reflects atherothrombosis: disruption of an atherosclerotic plaque followed by platelet activation and coagulation, with formation of an intraluminal thrombus…

…reentry tachyarrhythmias (AVNRT and AVRT). These arrhythmias rely on AV node transmission. By disrupting this transmission, the reentry and hence, the arrhythmia may be terminated…

…which results in thrombus formation (Figure 1). Disruption of an atherosclerotic plaque may also release atherosclerotic debris downstream, causing microvascular embolization (i.e occluding smaller…

…intima, and thrombus formation. Atherosclerosis is therefore not simply a disorder of lipid storage. Its biology includes: accumulation and modification of lipids within the intima…

…15–90 days. Chronic: more than 90 days. The central clinical danger is progressive aortic wall disruption, rupture and compromise of branch vessels. Type A…

…a major epicardial artery or bypass graft Side branch occlusion or thrombus Disruption of collateral flow Distal embolization Stent thrombosis Graft occlusion after CABG No…

…Papillary muscle rupture, producing acute severe mitral regurgitation (MR). These complications result from transmural myocardial necrosis and subsequent tissue disruption. Infarct expansion and, in some…

…platelet rich because they form under high shear conditions. Disruption of an atherosclerotic plaque or injury associated with PCI exposes thrombogenic material, promoting platelet activation…