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Obesity and Cardiovascular Disease: Assessment and Treatment

…disease (CAD), atherosclerosis, heart failure (HF), atrial fibrillation and cardiovascular events. In clinical practice, obesity is conventionally defined by a body mass index (BMI) of…

Statin Intolerance and Statin-Associated Muscle Symptoms

…Low body mass index Asian ancestry Previous muscle disease or a personal or family history of muscle disorders Acute infection Renal or hepatic impairment Hypothyroidism…

Mitral regurgitation

…disease typically results in thickening of the leaflets and may coexist with mitral stenosis. Idiopathic degeneration (Barlow's disease), degeneration associated with connective tissue disorders…

Primary Aldosteronism: Screening and Management

…relatives of patients with PA Patients with hypokalaemia may develop weakness, muscle cramps or, in severe cases, periodic paralysis. Nevertheless, many patients are normokalaemic and…

ECG changes due to electrolyte imbalance (disorder)

…Addison's disease and digoxin intoxication may also cause hyperkalemia. ECG in mild hyperkalemia (potassium 6,0 mmol/L) The earliest sign of hyperkalemia is…

Cardiac arrest due to electrolyte imbalance

…Addison's disease, renal insufficiency, therapeutic interventions with tamoxifen or lithium, thiazide administration, and over supplementation of calcium and vitamin D. ECG in hypercalcemia Typical…

Peripheral Artery Disease: Diagnosis, Ankle–Brachial Index and Risk Management

…Definition and pathophysiology Peripheral artery disease (PAD) is a clinical disorder caused by stenosis or occlusion of the aorta or arteries supplying the limbs. In…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…inflammatory disease of the arterial wall in which lipid accumulation, vascular cell dysfunction, immune cell recruitment, extracellular matrix remodelling, and thrombosis interact to produce focal…

ST-Elevation Myocardial Infarction: Diagnosis and Electrocardiographic Criteria

…costochondritis, and gastrointestinal disorders. Radiation of discomfort to the trapezius ridge is not seen in STEMI and suggests pericarditis instead. Pain is not uniformly present…

Preeclampsia and Hypertensive Pregnancy Disorders as Future Cardiovascular Risk

…disorders, but it may also arise de novo after delivery. New onset postpartum preeclampsia is increasingly recognized as a significant cause of maternal morbidity and…

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