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Obesity and Cardiovascular Disease: Assessment and Treatment

…disease (CAD), atherosclerosis, heart failure (HF), atrial fibrillation and cardiovascular events. In clinical practice, obesity is conventionally defined by a body mass index (BMI) of…

Statin Intolerance and Statin-Associated Muscle Symptoms

…Low body mass index Asian ancestry Previous muscle disease or a personal or family history of muscle disorders Acute infection Renal or hepatic impairment Hypothyroidism…

Mitral regurgitation

…disease typically results in thickening of the leaflets and may coexist with mitral stenosis. Idiopathic degeneration (Barlow's disease), degeneration associated with connective tissue disorders…

Primary Aldosteronism: Screening and Management

…major target—where MR activation promotes sodium transport—MRs are also present in cardiac myocytes, vascular smooth muscle, endothelial cells, macrophages, neurons and other tissues…

ECG changes due to electrolyte imbalance (disorder)

…Addison's disease and digoxin intoxication may also cause hyperkalemia. ECG in mild hyperkalemia (potassium 6,0 mmol/L) The earliest sign of hyperkalemia is…

Cardiac arrest due to electrolyte imbalance

…S Ca 2+ 2.6 mmol/L In approximately 90% of cases, hypercalcemia is attributed to primary hyperparathyroidism or neoplastic etiologies. Other causes include immobilization…

Peripheral Artery Disease: Diagnosis, Ankle–Brachial Index and Risk Management

…manifestation of systemic arterial disease rather than an isolated disorder of the lower limbs. Patients frequently have concomitant coronary, cerebrovascular or other peripheral arterial disease…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…a major site of disease, atherosclerosis is systemic and may affect multiple arterial territories. The arterial wall is biologically active. Endothelial and smooth muscle cells…

ST-Elevation Myocardial Infarction: Diagnosis and Electrocardiographic Criteria

…without acute elevations in cardiac troponin concentrations. Based on the presenting electrocardiogram (ECG) and the presence of troponin elevation, ACS are classified into unstable angina…

Preeclampsia and Hypertensive Pregnancy Disorders as Future Cardiovascular Risk

…complications. Seizures in a patient with preeclampsia indicate eclampsia. Postpartum disease is clinically important. Hypertension is most frequent in women who had antenatal hypertensive disorders…

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