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Metabolic Syndrome: Definition and Clinical Significance

…fibrinogen, plasminogen activator inhibitor 1, serum viscosity, asymmetric dimethylarginine, homocysteine, white blood cell count, proinflammatory cytokines and C reactive protein. Increased urinary albumin/creatinine ratio…

Microvascular Angina and INOCA: Diagnosis with CFR and IMR

…Endothelial dysfunction may contribute to both microvascular and epicardial vasomotor disorders. Endothelial activation can promote the release of adhesion molecules, inflammatory cytokines, and vasoconstricting mediators…

Colchicine and Anti-inflammatory Therapy in Coronary Disease

…activation of innate immune pathways, cytokine signalling and recruitment of inflammatory cells to vascular lesions. The interleukin 1β pathway, with downstream effects involving interleukin…

Cardiovascular effects of COVID-19 (Coronavirus Disease 2019)

…19 has caused an unprecedented number of severe and deadly infections among young and apparently healthy individuals. Infections and the risk of acute coronary syndromes…

Cardiovascular Risk in Inflammatory and Autoimmune Disease

…myositis, mixed connective tissue disease, Sjögren syndrome, SLE and APS. Some patient groups have a two to three fold greater prevalence of asymptomatic atherosclerotic cardiovascular…

Incretins in Cardiometabolic Medicine: Leveraging GLP-1, GIP, and Glucagon Receptor Agonism for Cardiovascular Risk Reduction

…smooth muscle cells, reducing cytokines like IL 6 and TNF α. 11 Plaque Stability: By reducing macrophage infiltration and inhibiting foam cell formation, they stabiliz

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…inflammatory disease of the arterial intima that serves as the fundamental pathophysiological substrate for acute coronary syndromes (ACS), including ST Elevation Myocardial Infarction (STEMI) [1] …

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