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Lipid-Lowering Therapy: Statins as First-Line Treatment

…a key enzyme in cholesterol synthesis. Reduced hepatic cholesterol synthesis produces a compensatory increase in hepatic LDL receptor expression, accelerating clearance of circulating LDL particles…

Metabolic Syndrome: Definition and Clinical Significance

…a more accurate assessment of atherogenic burden than LDL cholesterol alone in patients with diabetes. Insulin resistance is accompanied by compensatory hyperinsulinaemia and, with progression…

Aberrant ventricular conduction (aberrancy, aberration)

…periods. Aberrant conduction occurs when the length of the cardiac cycle is changed without a compensatory change in the length of the refractory period. This…

Alcohol withdrawal and delirium tremens: quick reference

…system adapts through reduced GABA mediated inhibition and increased glutamatergic activity. When the alcohol level suddenly falls, the compensatory excitation remains, producing tremor, sympathetic activation…

Alcohol and Cardiovascular Disease

…reduced systemic vascular resistance. The resulting mild reduction in blood pressure is often accompanied by a compensatory rise in cardiac output. Although these changes are…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…including branch points in the epicardial coronary arteries. Early lesions may undergo positive or compensatory remodelling, in which the vessel enlarges outward before a major…

Cardiac Tamponade: Recognition and Pericardiocentesis

…but are relatively insensitive findings. Some patients with subacute tamponade may initially remain normotensive or even hypertensive because of compensatory mechanisms. Beck’s Triad The…

P-wave, PR interval, PR segment: physiology, criteria & ECG findings

…in Figure 3. If an atria becomes enlarged (typically as a compensatory mechanism) its contribution to the P wave will be enhanced. Enlargement of the…

Aortic stenosis

…stroke volume becomes smaller. Reduced stroke volumes and increased resistance in the valve result in compensatory left ventricular hypertrophy . This allows the left ventricle to…

Ejection fraction (EF): Physiology, Measurement & Clinical Evaluation

…ventricular volumes tend to have high ejection fractions. This inverse relationship appears to be a compensatory mechanism, such that small ventricular volumes are compensated with…

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