…thickness. Macrophage derived matrix metalloproteinases (MMPs) degrade the interstitial collagen of the cap, leading to structural failure. Rupture exposes highly thrombogenic subendothelial matrix components, notably…

…producing abundant extracellular matrix (ECM) components, primarily interstitial collagen types I and III, elastin, and proteoglycans [6] . This matrix forms a fibrous cap that sequesters…

…reduces thrombogenicity, and favourably modifies inflammatory and collagen related components of atherosclerotic plaque. These effects help explain why reductions in cardiovascular events are substantially greater…

…coronary occlusion. Plaque rupture typically involves a thin, collagen poor fibrous cap overlying a large lipid core with many macrophages, resulting in a red, fibrin…

…vessels. The visceral layer consists of mesothelian cells, collagen and elastin and is fused with the myocardium. At the departures of the larger vessels, the…

…degenerative disease (fibrosis) Myocardial ischemia/infarction Lesions due to heart surgery Myocarditis Collagen disease Amyloidosis Risk of supraventricular tachyarrhythmia (tachycardia) Sinus node dysfunction is also…

…causes of nonspecific intraventricular conduction delay According to the American Heart Association/American College of Cardiology and the Heart Rhythm Society (AHA/ACCF/HRS) recommendations…

…from the European Society of Cardiology (ESC), American College of Cardiology (ACC) and American Heart Association (AHA). The formula takes into account the following variables…

…advent of highly sensitive cardiac biomarkers, the European Society of Cardiology (ESC), American College of Cardiology (ACC), American Heart Association (AHA), and World Heart Federation …

…myoardial infarction. An important discovery was reported in 1930 when Buchner and colleages showed that myocardial contractility was closely related to myocardial blood flow. This…