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Chronic Kidney Disease as a Cardiovascular Risk Factor

…Non traditional cardiovascular mechanisms include: Uraemia associated inflammation Oxidative stress Vascular dysfunction Promotion of vascular calcification Albuminuria and proteinuria Neurohormonal activation Plasma volume expansion Myocardial…

Constrictive pericarditis: definition, causes, diagnosis & echocardiography

…the end stage of pericardial inflammation Constrictive pericarditis is the result of chronic inflammation of the pericardium. In principle, all causes of pericarditis can result…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

Cardiology Myocardial ischemia and infarction Definition and pathophysiology Atherosclerosis is a chronic, inflammatory disease of the arterial wall in which lipid accumulation, vascular cell dysfunction…

Obesity and Cardiovascular Disease: Assessment and Treatment

…Chronic, low grade systemic inflammation Insulin resistance Abnormal adipokine signalling Endothelial dysfunction Dyslipidaemia A prothrombotic state Albuminuria and declining estimated glomerular filtration rate Development of…

Colchicine and Anti-inflammatory Therapy in Coronary Disease

…neutrophil chemotaxis toward inflammatory sites. Its cardiovascular effects therefore appear to reflect modulation of vascular inflammation rather than lipid lowering. Other anti inflammatory strategies have…

ACE Inhibitor Cough and Angioedema: Practical Management

…ACE) inhibitors are foundational therapies in cardiovascular medicine, widely utilized for the management of hypertension, chronic ischemic heart disease, heart failure with reduced ejection fraction …

Pericarditis, myocarditis & perimyocarditis: ECG, criteria & treatment

…roots of the great vessels are contained (Figure 1). The pericardial sac encloses the pericardial cavity which contains pericardial fluid. Numerous conditions may cause inflammation…

SGLT2 Inhibitors for Cardiovascular and Renal Protection

…activity Attenuation of oxidative stress, inflammation and fibrosis Reduction in body weight and haemoglobin A1c Increased uricosuria, with plasma uric acid reduction of approximately 10…

Myocardial Perfusion Imaging With SPECT and PET

…PET. Evaluate myocardial viability, particularly when combined with metabolic imaging. Contribute to assessment of cardiac inflammation, infective endocarditis, and cardiac amyloidosis using appropriate radiopharmaceuticals. Functional…

Introduction to Coronary Artery Disease (Ischemic Heart Disease)

…passive deposition of lipids into the coronary artery walls; indeed, atherosclerosis is a disease in which the immune system elicits an active inflammation within the…

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