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Familial and Genetic Screening in Premature Cardiovascular Disease

…thromboembolic disorders. Most recognised heritable cardiovascular conditions demonstrate autosomal dominant transmission, in which an affected heterozygous individual has a 50% risk of transmitting the relevant…

Smoking Cessation: Pharmacotherapy and Cardiovascular Benefit

…smokers for a prolonged period. In heavy smokers, cardiovascular risk falls within five years of stopping but may remain elevated thereafter. The overall health benefit…

Familial Hypercholesterolaemia: Diagnosis, Cascade Screening and Treatment

…approximately 1 in 250–300 people and is the most common inherited metabolic disorder associated with premature cardiovascular disease. Prevalence is higher in populations with…

Peripheral Artery Disease: Diagnosis, Ankle–Brachial Index and Risk Management

…clinical disorder caused by stenosis or occlusion of the aorta or arteries supplying the limbs. In adults over 40 years of age, atherosclerosis is the…

No-Reflow Phenomenon During Percutaneous Coronary Intervention: Prevention and Treatment

…It is therefore a disorder of coronary microvascular perfusion rather than persistent obstruction of the treated epicardial segment. The phenomenon occurs in approximately 2%–3…

Secondary Hypertension: When and How to Investigate

…should be considered in every patient with newly diagnosed or referred hypertension, with particular vigilance when the clinical history includes hypokalaemia. Endocrine disorders account for…

Differential Diagnosis of Chest Pain: A Clinical Overview

…diagnosis, as the syndrome associated with ischemic heart disease is broader than chest pain itself, encompassing symptoms like tightness, pressure, and discomfort in the chest…

Preeclampsia and Hypertensive Pregnancy Disorders as Future Cardiovascular Risk

…novo after delivery. New onset postpartum preeclampsia is increasingly recognized as a significant cause of maternal morbidity and mortality during the postpartum period. Maternal and…

Cardiovascular Risk in Inflammatory and Autoimmune Disease

…Behçet disease can cause both arterial and venous thrombosis. In SLE, renal artery involvement may contribute to difficult to control hypertension. The cardiovascular consequences of

Cardiovascular Risk Assessment with SCORE2 and SCORE2-OP

…of the overall burden of atherosclerotic cardiovascular disease. SCORE2 is intended principally for adults aged 40–69 years, whereas SCORE2 OP is used in adults…

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