Fosamax Alendronat Sandoz Fosavance Aminobisphosphonate First-line agent for osteoporosis and the best-documented fracture-preventing treatment in primary care. Efficacy for vertebral and hip…

…no clinically significant negative inotropic effect and can therefore be used in heart failure with reduced ejection fraction when blood pressure or angina requires it…

…product can therefore be prescribed in two entirely different ways: as a fixed dose morning and evening with a separate SABA as needed, or as…

…effect can be steered minute by minute. Selective for smooth muscle in the vessel wall: lowers systemic vascular resistance without affecting contractility, conduction, or filling…

…1 mg intramuscularly is the treatment that a family member can give when the patient cannot swallow and intravenous access is unavailable — the effect arrives…

…renal failure, in the bleeding-prone patient, and when surgery or thrombolysis may become necessary at short notice. The disadvantages are continuous infusion, an unpredictable…

…needed use and can be discontinued with rapid recovery of renal function and platelet function. The short duration is also why three to four doses…

…care, and one of the reasons Sweden maintains a favourable resistance situation. The spectrum covers group A streptococci and pneumococci but not Haemophilus influenzae or…

…is slowed. The half-life of a few seconds means both the effect and side effects are over before one can regret it, but requires…

…the timing of administration a genuine treatment variable and not a formality. The most clinically important adverse effect is delayed: cholestatic liver injury can present…

…particular sulphonylurea require follow-up infusion and hours of monitoring, whereas a missed meal in a type 1 diabetic can be managed with a sandwich.