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The Fourth Universal Definition of Myocardial Infarction: Types 1–5

…pathophysiology Type 1 MI results from acute coronary atherothrombosis. It is usually precipitated by disruption of an atherosclerotic plaque through rupture or erosion. The relative…

Type 2 Myocardial Infarction: Mechanisms and Management

…infarction Definition and Pathophysiology Type 2 myocardial infarction (MI) is defined as an ischaemic myocardial injury occurring in the context of a mismatch between myocardial…

Type 2 Diabetes and Cardiovascular Risk Management

…across the spectrum of left ventricular ejection fraction AF and other arrhythmias Ischaemic stroke PAD CKD with associated cardiovascular complications Symptoms are determined by the…

Unstable Angina: Definition and Contemporary Management

…microvascular disease and vasospasm may coexist with atherosclerosis or may be the dominant cause of ischaemia. Other mechanisms capable of obstructing coronary arteries include embolism…

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

Cardiology Coronary Atherosclerosis Coronary atherosclerosis is a chronic, progressive, and highly complex lipid driven inflammatory disease of the arterial intima that serves as the fundamental…

Immediate Management of Type A and Type B Aortic Dissection

…90 days. The central clinical danger is progressive aortic wall disruption, rupture and compromise of branch vessels. Type A disease may cause cardiac tamponade, severe…

Cardiovascular effects of COVID-19 (Coronavirus Disease 2019)

…outcomes. The vast majority of infections with COVID 19 result in mild disease, with symptoms similar to seasonal flu (influenza) and other viral respiratory infections…

Inclisiran and Emerging Lipid-Lowering Agents

…is required. Combination therapy should be selected according to the magnitude of additional LDL C lowering needed and the patient’s prior treatment. Inclisiran is…

Stent Thrombosis: Timing, Causes, Diagnosis, and Prevention

…of the stent, stent diameter less than 3 mm, long stent length Large thrombotic burdens increase procedural risk because thrombus can fragment, embolize to other…

Ezetimibe: Place in Therapy and Expected LDL-C Reduction

…therapy remains the foundation of lipid lowering treatment for patients with chronic coronary syndrome, acute coronary syndrome (ACS), atherosclerotic peripheral arterial disease, and other very…

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