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Bempedoic Acid: Evidence and Clinical Use

…87 95% confidence interval: 0.79–0.96 P = .004 Other summaries of the trial describe a 14% reduction in the same composite outcome…

ACE Inhibitor Cough and Angioedema: Practical Management

…of the airway is paramount to evaluate for impending respiratory compromise. Diagnostics The diagnosis of ACE inhibitor induced cough is primarily clinical and relies on…

Colchicine and Anti-inflammatory Therapy in Coronary Disease

…colchicine requires attention to the balance between reduction in ischaemic events and possible infectious or other non cardiovascular adverse outcomes. Mechanisms of action Colchicine Colchicine…

Hypertensive crisis: drugs and doses

…hypertensive emergency. It summarises the mechanism of action, the onset, the duration of effect, the dosing, the adverse effects and the important precautions. A hypertensive…

Adenosine for tachyarrhythmias (AVNRT, AVRT, NCT)

…in patients on digoxin or verapamil, although this is not an established drug interaction. The half life of adenosine is 8 seconds. Adverse effects are…

Edrophonium test

…troublesome adverse effects, give a further 8 mg intravenously , slowly. Rapid injection increases the risk of nicotinic effects with paradoxically increasing weakness. 6. Assess the…

Levosimendan (Simdax, Simendan) in acute heart failure

…involving 192 patients with cardiogenic shock, researchers compared the effectiveness of milrinone and dobutamine . The primary composite outcome included in hospital mortality, resuscitated cardiac arrest…

Alcohol and Cardiovascular Disease

…more recent analyses question whether this reflects true biological protection. Potentially favourable associations with myocardial infarction may coexist with adverse effects on stroke, heart failure…

Type 2 Diabetes and Cardiovascular Risk Management

…arrhythmogenesis through diabetic neuropathy and adverse metabolic effects, independently of coexisting CAD, previous myocardial infarction or HF. Nevertheless, the risk of arrhythmia and sudden cardiac…

Atrial fibrillation: ECG, classification, causes, risk factors & management

…are at increased risk of cardiovascular mortality in general. This is not surprising given the adverse effects of long periods of tachycardia and desynchronized atrial…

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