…creatinine ≥133 µmol/L Rivaroxaban 20 mg once daily with food 15 mg once daily at eGFR 15 49 mL/min Edoxaban 60 mg once…

…with symptomatic HFrEF. The guideline defined population includes: LVEF ≤35%; sinus rhythm; resting heart rate ≥70 beats/min; persistent symptoms despite evidence based therapy with…

…myocarditis or pulmonary embolism is often a reversible arrhythmia with low risk of recurrence. Atrial fibrillation in other circumstances (particularly those listed above) is usually…

…doses per day are needed. Dose adjustment Situation Adjustment : : eGFR < 30 mL/min Avoid morphine (the active metabolite accumulates). Oxycodone at a reduced dose…

…molecular weight heparin. Consider the bleeding risk with gastrointestinal and urogenital tumours Marked renal failure Low molecular weight heparin with dose adjustment, or warfarin Subsegmental…

…dose adjustment is required for patients with mild to moderate hepatic impairment (Child Pugh Class A and B). Limited experience exists for patients with mild…

…Response to treatment should be reviewed after initiation and after each adjustment. Persistent symptoms despite appropriately titrated medical therapy should prompt consideration of coronary angiography…

…and severe bradycardia. Patients should be monitored for arrhythmias and QT prolongation with each dose adjustment, typically waiting 2 to 3 days to attain a…

…contraindication) . Irregular wide complex tachycardia is most often due to atrial fibrillation with wide QRS complexes due to bundle branch blocks or other conduction defects…

…36 mm 13 17 mm/m2 Aortic arch 22 36 mm Descending aorta 20 30 mm ​Adjustment refers to adjusting for body surface area (BSA)…