…discuss with the on call coagulation service Always in parallel: mechanical control of bleeding, tranexamic acid where it is not contraindicated, and contact with the…

…Dose adjustment is required in severe hepatic or renal impairment, and clinically relevant interactions occur with CYP3A4 inhibitors and inducers. Clinical indications Heart failure with…

…models in which adjustment has been made for confounders) individuals with atrial fibrillation are at five times increased risk of stroke and two times increased…

…approximate. When switching between opioids, cross tolerance is incomplete: reduce the calculated equianalgesic dose by 25–50 per cent and titrate. At a high dose…

…molecular weight heparin. Consider the bleeding risk with gastrointestinal and urogenital tumours Marked renal failure Low molecular weight heparin with dose adjustment, or warfarin Subsegmental…

…active metabolite and increased bleeding risk compared to patients weighing ≥ 60 kg. Renal impairment No dose adjustment is required, including for patients with end stage…

…guideline discussion. By contrast, the benefit of beta blockers in patients with CAD without previous MI and with normal LVEF is uncertain. Similarly, evidence for…

…proarrhythmia, and severe bradycardia. Patients should be monitored for arrhythmias and QT prolongation with each dose adjustment, typically waiting 2 to 3 days to attain…

…this transmission, the reentry and hence, the arrhythmia may be terminated. Generally, adenosine is considered safe for patients with narrow complex tachycardia (NCT). Adenosine typically…

…et al. (2003): Recommendations for evaluation of the severity of native valvular regurgitation with two dimensional and Doppler echocardiography. In Journal of the American Society…