…creatinine ≥133 µmol/L Rivaroxaban 20 mg once daily with food 15 mg once daily at eGFR 15 49 mL/min Edoxaban 60 mg once…

…Dose adjustment is required in severe hepatic or renal impairment, and clinically relevant interactions occur with CYP3A4 inhibitors and inducers. Clinical indications Heart failure with…

…multivariable models (i.e statistical models in which adjustment has been made for confounders) individuals with atrial fibrillation are at five times increased risk of…

…doses per day are needed. Dose adjustment Situation Adjustment : : eGFR < 30 mL/min Avoid morphine (the active metabolite accumulates). Oxycodone at a reduced dose…

…molecular weight heparin. Consider the bleeding risk with gastrointestinal and urogenital tumours Marked renal failure Low molecular weight heparin with dose adjustment, or warfarin Subsegmental…

…dose adjustment is required for patients with mild to moderate hepatic impairment (Child Pugh Class A and B). Limited experience exists for patients with mild…

…of long term cardiovascular outcomes. With the important exception of beta blockers in selected patients after acute myocardial infarction (MI), antianginal drugs have not been…

…and severe bradycardia. Patients should be monitored for arrhythmias and QT prolongation with each dose adjustment, typically waiting 2 to 3 days to attain a…

…transmission through the atrioventricular (AV) node, thereby interfering with the pathway that enables reentry tachyarrhythmias (AVNRT and AVRT). These arrhythmias rely on AV node transmission…

…36 mm 13 17 mm/m2 Aortic arch 22 36 mm Descending aorta 20 30 mm ​Adjustment refers to adjusting for body surface area (BSA)…