…undergoes extensive first pass hepatic metabolism through CYP3A4. Dose adjustment is required in severe hepatic or renal impairment, and clinically relevant interactions occur with CYP3A4…

…and available treatments In multivariable models (i.e statistical models in which adjustment has been made for confounders) individuals with atrial fibrillation are at five…

…doses per day are needed. Dose adjustment Situation Adjustment : : eGFR < 30 mL/min Avoid morphine (the active metabolite accumulates). Oxycodone at a reduced dose…

…molecular weight heparin. Consider the bleeding risk with gastrointestinal and urogenital tumours Marked renal failure Low molecular weight heparin with dose adjustment, or warfarin Subsegmental…

…adjustment is required, including for patients with end stage renal disease. Limited experience exists for patients with impaired renal function. Hepatic impairment No dose adjustment…

…antithrombotic treatment form the broader management framework. Response to treatment should be reviewed after initiation and after each adjustment. Persistent symptoms despite appropriately titrated medical…

…and severe bradycardia. Patients should be monitored for arrhythmias and QT prolongation with each dose adjustment, typically waiting 2 to 3 days to attain a…

…12 or 16 mg. Renal failure or renal replacement therapy No dosage adjustment is required in renal failure or renal replacement therapy. Pediatric patients Body…

…36 mm 13 17 mm/m2 Aortic arch 22 36 mm Descending aorta 20 30 mm ​Adjustment refers to adjusting for body surface area (BSA)…