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Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…of the arterial wall in which lipid accumulation, vascular cell dysfunction, immune cell recruitment, extracellular matrix remodelling, and thrombosis interact to produce focal arterial lesions…

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…LDL (oxLDL) is highly immunogenic and acts as a potent chemoattractant. Circulating monocytes bind to the upregulated adhesion molecules, transmigrate into the intima via diapedesis…

Microvascular Angina and INOCA: Diagnosis with CFR and IMR

…or left ventricular hypertrophy. Hypertension, diabetes, and elevated NT proBNP are more frequent in this pattern. Endothelial dysfunction may contribute to both microvascular and epicardial…

Heart Failure with Preserved Ejection Fraction (HFpEF)

…clinical syndrome characterized by the cardinal symptoms and signs of heart failure (HF) in the presence of a left ventricular ejection fraction (LVEF) of ≥50%…

Non-ST Elevation Acute Myocardial Infarction (NSTEMI) and Unstable Angina

…plaque to a highly thrombogenic surface occurs via three primary mechanisms: Plaque Rupture: Accounting for 60 70% of ACS presentations, plaque rupture typically occurs in…

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