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Long QT (QTc) interval, long QT syndrome (LQTS) & torsades de pointes

…peak plasma concentrations of that drug. The QT interval should be adjusted for heart rate. Long QT interval causes long QT syndrome An abnormally prolonged…

The Fourth Universal Definition of Myocardial Infarction: Types 1–5

…abnormality in an ischaemic pattern. Identification of a coronary thrombus by angiography or autopsy, except in type 2 and type 3 MI. A diagnosis of…

Heart Failure With Mildly Reduced Ejection Fraction

…cardiac abnormality Evidence such as increased left atrial size, left ventricular hypertrophy or abnormal LV filling supports the diagnosis Unlike HFpEF, objective evidence of structural…

Left atrial enlargement (P mitrale) & right atrial enlargement (P pulmonale) on ECG

…hypertrophy, which is why some experts have suggested that the term atrial abnormality be used instead of enlargement. Atrial enlargement/abnormality often accompanies ventricular enlargement…

Liver parameters

…suggests advanced fibrosis Work up of unexplained raised liver tests Repeat the tests first — a transient rise is common. If the abnormality persists: hepatitis serology…

Coronary Anomalies and Myocardial Bridging

…amplify the abnormality through increased myocardial contractility and heart rate. Coronary compression and a Venturi or “suction” effect have been proposed as mechanisms of inducible…

Heart Failure With Preserved Ejection Fraction: Diagnosis and Treatment

…burden of cardiovascular and non cardiovascular comorbidity than patients with reduced EF. Pathophysiology Abnormal ventricular relaxation and increased filling pressures The central hemodynamic abnormality in…

No-Reflow Phenomenon During Percutaneous Coronary Intervention: Prevention and Treatment

…to the angiographic appearance of the treated epicardial artery, because the defining abnormality is inadequate distal perfusion in the absence of a major residual epicardial…

Stress Echocardiography: Protocols and Interpretation

…coronary artery disease (CAD). It combines echocardiographic assessment of left ventricular (LV) structure and function with exercise or pharmacological stress. The physiological basis is an…

T-waves in ischemia: hyperacute, inverted (negative), Wellen's sign & de Winter's sign

ECG Myocardial ischemia and infarction T wave changes in acute myocardial infarction & ischemia A thorough discussion regarding the physiology of the T wavewas previously provided…

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