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Chronic Heart Failure With Reduced Ejection Fraction: Four-Pillar Therapy

…on left ventricular ejection fraction (LVEF). Heart failure with reduced ejection fraction (HFrEF) is defined by the combination of symptoms, with or without physical signs…

Pharmacologic agents in myocardial perfusion imaging

…cGMP. It also inhibits the cellular reuptake of adenosine into endothelial cells. Further, it inhibits adenosine deaminase, which is responsible for breaking down adenosine. These…

Regional Myocardial Contractile Function: Wall Motion Abnormalities

…used interchangeably throughout this text. Wall motion abnormalities in ischemic heart disease In the setting of stable ischemic heart disease, an atherosclerotic plaque causes ischemia…

Interpretation of neonatal and pediatric electrocardiograms (ECG)

…interpretation in adults. The ECG must always be interpreted using a systematic approach in order to minimize the probability of missing significant abnormalities. The following…

The Fourth Universal Definition of Myocardial Infarction: Types 1–5

…include depletion of glycogen, relaxation of myofibrils, and disruption of the sarcolemma. These changes may appear within 10–15 minutes of ischaemia. Mitochondrial abnormalities can…

Interpretation of myocardial perfusion images (Myocardial SPECT / PET)

…or other pathologies. The software allows for detailed regional analysis of myocardial perfusion, highlighting specific segments of the left ventricle that demonstrate abnormalities. These tools…

NSTEMI: Risk Stratification and Timing of the Invasive Strategy

…the absence of persistent ST segment elevation. This does not imply low risk: patients with NSTE ACS may have substantial myocardial ischaemia, dynamic ECG abnormalities…

Fractional shortening for estimation of ejection fraction

…25% Normal FS, 2D measurement 18% Advantages of fractional shortening If ventricular geometry is normal and there are no regional wall motion abnormalities, then fractional…

Metabolic Syndrome: Definition and Clinical Significance

…syndrome is therefore both a clinical risk factor cluster and a marker of broader metabolic dysfunction. Associated abnormalities may include increased apoB and apoC III…

Chronic Kidney Disease as a Cardiovascular Risk Factor

…Nephrology Definition and pathophysiology Chronic kidney disease (CKD) is defined by abnormalities of renal structure or function that persist for more than 3 months and…

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